Watertown MA - 3D BioLabs has published a landmark study in the journal Proceedings of the National Academy of Sciences demonstrating a strategy for liver tissue engineering and replacement in collaboration with Veryst Engineering (Needham, MA).
This study, entitled “Implantable 3D printed hydrogels with intrinsic channels for liver tissue engineering," describes the design of a 3D printed hydrogel device with stable fluidic integrations suitable for surgical implantation. Intrinsic millifluidic channels connected to blood vessels support functional liver tissue through the nanoporous 3D printed material.
Blood perfusion is a significant requirement for tissue viability that typically limits scalability of potential functional tissue-engineered organ implants. In this study, active perfusion improves viability and function of hepatocytes (liver cells). The intrinsic architecture of the device facilitates scaling of tissue mass, thus holding promise for therapeutic tissue replacement applications.
Comments